מחקרים רפואיים
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פרופ' קופילוב עוסק רבות במחקר רפואי בתחום מחלות המעי הדלקתיות.
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תחומי העניין העיקריים כוללים ניטור ומעקב אנדוסקופי והדמייתי במחלות מעי דלקתיות, קפסולה אנדוסקופית, ביומרקרים ומנגנוני ניטור תרופות.
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פרופ' קופילוב חבר בפורומים קליניים ומדעיים של ארגון קרוהן וקוליטיס האירופאי (ECCO) ושותף לכתיבת הנחיות קליניות
אירופאיות בתחום.
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עד כה פירסם מעל 100 מאמרים מדעיים בספרות הרפואית העולמית.
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מציג בקביעות בכנסים מדעיים בארץ ובחו"ל כגון כנס ECCO, כנס UEGW ,DDW, כנס איגוד הגסטרו הישראלי ועוד.
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פרופ' קופילוב מוזמן להרצות בנושאי המחקר שלו, באופן קבוע בישראל ובחו"ל
Cytomegalovirus Infection in Pediatric Severe Ulcerative Colitis-A Multicenter Study from the Pediatric Inflammatory Bowel Disease Porto Group of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition.
Cohen S, Martinez-Vinson C, Aloi M, Turner D, Assa A, de Ridder L, Wolters VM, de Meij T, Alvisi P, Bronsky J, Kopylov U; Pediatric IBD Porto Group of ESPGHAN.
Pediatr Infect Dis J. 2018 Mar;37(3):197-201. doi: 10.1097/INF.0000000000001724.
PMID: 29424814 [PubMed - in process]
The Lewis score or the capsule endoscopy Crohn's disease activity index: which one is better for the assessment of small bowel inflammation in established Crohn's disease?
Yablecovitch D, Lahat A, Neuman S, Levhar N, Avidan B, Ben-Horin S, Eliakim R, Kopylov U.
Therap Adv Gastroenterol. 2018 Jan 14;11:1756283X17747780. doi: 10.1177/1756283X17747780.
eCollection 2018.
PMID: 29399042 [PubMed] Free PMC Article
Capsule Endoscopy, Magnetic Resonance Enterography, and Small Bowel Ultrasound for Evaluation of Postoperative Recurrence in Crohn's Disease: Systematic Review and Meta-Analysis.
Yung DE, Har-Noy O, Tham YS, Ben-Horin S, Eliakim R, Koulaouzidis A,
Kopylov U.
Inflamm Bowel Dis. 2017 Dec 19;24(1):93-100. doi: 10.1093/ibd/izx027.
PMID: 29272490 [PubMed - in process]
Capsule endoscopy validation of the magnetic enterography global score in patients
with established Crohn's disease.
Klang E, Amitai MM, Lahat A, Yablecovitch D, Avidan B, Neuman S, Levhar N, Rozendorn N, Weiss B, Ben-Horin S, Eliakim R, Kopylov U; Israeli IBD research Nucleus (IIRN).
J Crohns Colitis. 2017 Nov 22. doi: 10.1093/ecco-jcc/jjx156. [Epub ahead of print]
PMID: 29182750 [PubMed - as supplied by publisher]
Vedolizumab in IBD-Lessons From Real-world Experience;
A Systematic Review and Pooled Analysis.
Engel T, Ungar B, Yung DE, Ben-Horin S, Eliakim R, Kopylov U.
J Crohns Colitis. 2018 Jan 24;12(2):245-257. doi: 10
1093/ecco-jcc/jjx143.
PMID: 29077833 [PubMed - in process]
The Association Between Drug Levels and Endoscopic Recurrence in Postoperative Patients with Crohn's Disease Treated with Tumor Necrosis Factor Inhibitors.
Fay S, Ungar B, Paul S, Levartovsky A, Yavzori M, Fudim E, Picard O, Eliakim R, Ben-Horin S, Roblin X, Kopylov U.
Inflamm Bowel Dis. 2017 Nov;23(11):1924-1929. doi: 10.1097/
MIB.0000000000001220.
PMID: 28837524 [PubMed - in process]
Impact of Infliximab and Cyclosporine on the Risk of Colectomy in Hospitalized Patients with Ulcerative Colitis Complicated by Cytomegalovirus-A Multicenter Retrospective Study.
Kopylov U, Papamichael K, Katsanos K, Waterman M, Bar-Gil Shitrit A, Boysen T, Portela F, Peixoto A, Szilagyi A, Silva M, Maconi G, Har-Noy O, Bossuyt P, Mantzaris G, Barreiro de Acosta M, Chaparro M, Christodoulou DK, Eliakim R, Rahier JF, Magro F, Drobne D, Ferrante M, Sonnenberg E, Siegmund B, Muls V, Thurm T, Yanai H, Dotan I, Raine T, Levin A, Israeli E, Ghalim F, Carbonnel F, Vermeire S, Ben-Horin S, Roblin X. Inflamm Bowel Dis. 2017 Sep;23(9):1605-1613. doi: 10.1097/MIB.0000000000001160. PMID: 28590343 [ - in process]
Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn's disease: Systematic review and meta-analysis.
Kopylov U, Yung DE, Engel T, Vijayan S, Har-Noy O, Katz L, Oliva S, Avni T, Battat R, Eliakim R, Ben-Horin S, Koulaouzidis A.
Dig Liver Dis. 2017 Aug;49(8):854-863. doi: 10.1016/j.dld.2017.04.013
Epub 2017 Apr 27. Review.
PMID: 28512034 [PubMed - in process]
Association of Induction Infliximab Levels With Clinical Response
in Perianal Crohn's Disease.
Davidov Y, Ungar B, Bar-Yoseph H, Carter D, Haj-Natour O, Yavzori M, Chowers Y, Eliakim R,
Ben-Horin S, Kopylov U.
J Crohns Colitis. 2017 May 1;11(5):549-555. doi: 10.1093/ecco-jcc/jjw182.
PMID: 28453755 [PubMed - in process]
Association Between Ustekinumab Trough Concentrations and Clinical, Biomarker, and Endoscopic Outcomes in Patients With Crohn's Disease.
Battat R, Kopylov U, Bessissow T, Bitton A, Cohen A, Jain A, Martel M, Seidman E, Afif W.
Clin Gastroenterol Hepatol. 2017 Sep;15(9):1427-1434.e2. doi: 10.1016/j.cgh.2017.03.032
. Epub 2017 Mar 29.
PMID: 28365485 [PubMed - in process]
Efficacy and Safety of Vedolizumab for Induction of Remission in Inflammatory Bowel Disease-the Israeli Real-World Experience.
Kopylov U, Ron Y, Avni-Biron I, Koslowsky B, Waterman M, Daher S, Ungar B, Yanai H, Maharshak N, Ben-Bassat O, Lichtenstein L, Bar-Gil Shitrit A, Israeli E, Schwartz D, Zittan E, Eliakim R, Chowers Y, Ben-Horin S, Dotan I.
Inflamm Bowel Dis. 2017 Mar;23(3):404-408. doi: 10.1097/MIB.0000000000001039.
PMID: 28178003 [PubMed - in process]
Genetic Predictors of Benign Course of Ulcerative Colitis-A North American Inflammatory Bowel Disease Genetics Consortium Study.
Kopylov U, Boucher G, Waterman M, Rivers CR, Patel M, Cho JH, Colombel JF, Duerr RH, Binion D, McGovern DP, Schumm PP, Brant SR, Silverberg MS, Rioux JD, Bitton A.
Inflamm Bowel Dis. 2016 Oct;22(10):2311-6. doi: 10.1097/MIB.0000000000000913.
PMID: 27575496 [PubMed - indexed for MEDLINE] Free PMC Article
Magnetic resonance enterography versus capsule endoscopy activity indices for quantification of small bowel inflammation in Crohn's disease.
Kopylov U, Klang E, Yablecovitch D, Lahat A, Avidan B, Neuman S, Levhar N, Greener T, Rozendorn N, Beytelman A, Yanai H, Dotan I, Chowers Y, Weiss B, Ben-Horin S, Amitai MM, Eliakim R; Israeli IBD research Nucleus (IIRN).
Therap Adv Gastroenterol. 2016 Sep;9(5):655-63. doi: 10.1177/1756283X16649143. Epub 2016 May 22.
PMID: 27582877 [PubMed] Free PMC Article
European experience with methotrexate treatment in Crohn's disease:
a multicenter retrospective analysis.
Kopylov U, Katsanos KH, van der Woude CJ, Karmiris K, Hernandez V, Odes S, Papamichael K, Koutroubakis IE, Bojic D, Kaimakliotis I, Fiorino G, Papageorgiou N, Pineda JR, Strongili K, Sanroman L, Mantzaris GJ, Jojic N, Paspatis G, Christodoulou DK, Ben-Horin S, Tsianos EV. Eur J Gastroenterol Hepatol. 2016 Jul;28(7):802-6. doi: 10.1097/MEG.0000000000000609.
PMID: 26894634 [PubMed - indexed for MEDLINE]
Detection of Small Bowel Mucosal Healing and Deep Remission in Patients With Known Small Bowel Crohn's Disease Using Biomarkers, Capsule Endoscopy, and Imaging.
Kopylov U, Yablecovitch D, Lahat A, Neuman S, Levhar N, Greener T, Klang E, Rozendorn N, Amitai MM,
Ben-Horin S, Eliakim R.
Am J Gastroenterol. 2015 Sep;110(9):1316-23. doi: 10.1038/ajg.2015.221. Epub 2015 Jul 28.
PMID: 26215531 [PubMed - indexed for MEDLINE
Risk of Lymphoma, Colorectal and Skin Cancer in Patients with IBD Treated with Immunomodulators and Biologics: A Quebec Claims Database Study.
Kopylov U, Vutcovici M, Kezouh A, Seidman E, Bitton A, Afif W.
Inflamm Bowel Dis. 2015 Aug;21(8):1847-53. doi: 10.1097
/MIB.0000000000000457.
PMID: 25993693 [PubMed - indexed for MEDLINE]
Small bowel capsule endoscopy in the management of established Crohn's disease: clinical impact, safety, and correlation with inflammatory biomarkers.
Kopylov U, Nemeth A, Koulaouzidis A, Makins R, Wild G, Afif W, Bitton A, Johansson GW, Bessissow T, Eliakim R, Toth E,
Seidman EG.
Inflamm Bowel Dis. 2015 Jan;21(1):93-100. doi: 10.1097/MIB.0000000000000255.
PMID: 25517597 [PubMed - indexed for MEDLINE]
Adalimumab monotherapy versus combination therapy with immunomodulators in patients with Crohn's disease: a systematic review and meta-analysis.
Kopylov U, Al-Taweel T, Yaghoobi M, Nauche B, Bitton A, Lakatos PL, Ben-Horin S, Afif W, Seidman EG.
J Crohns Colitis. 2014 Dec;8(12):1632-41. doi: 10.1016/j.crohns.2014.07.003. Epub
2014 Jul 25. Review.
PMID: 25067824 [PubMed - indexed for MEDLINE]
Subcutaneous ustekinumab for the treatment of anti-TNF resistant
Crohn's disease--the McGill experience.
Kopylov U, Afif W, Cohen A, Bitton A, Wild G, Bessissow T, Wyse J, Al-Taweel T, Szilagyi A, Seidman E.
J Crohns Colitis. 2014 Nov;8(11):1516-22. doi: 10.1016/j.crohns.2014.06.005.
Epub 2014 Jul 1.
PMID: 24996483 [PubMed - indexed for MEDLINE]
Prior varicella zoster virus exposure in IBD patients treated by anti-TNFs and other immunomodulators: implications for serological testing and vaccination guidelines.
Kopylov U, Levin A, Mendelson E, Dovrat S, Book M, Eliakim R, Ben-Horin S.
Aliment Pharmacol Ther. 2012 Jul;36(2):145-50. doi: 10.1111/j.1365-2036.2012.05150.x. Epub 2012 May 22. Erratum in: Aliment Pharmacol Ther. 2018 Jan;47(1):156.
PMID: 22612376 [PubMed - indexed for MEDLINE] Free Article
Anti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis.
Kopylov U, Ben-Horin S, Zmora O, Eliakim R, Katz LH.
Inflamm Bowel Dis. 2012 Dec;18(12):2404-13. doi: 10.1002/ibd.22954. Epub
2012 Mar 29. Review.
PMID: 22467533 [PubMed - indexed for MEDLINE]
The efficacy of shortening the dosing interval to once every six weeks in Crohn's patients losing response to maintenance dose of infliximab.
Kopylov U, Mantzaris GJ, Katsanos KH, Reenaers C, Ellul P, Rahier JF, Israeli E, Lakatos PL, Fiorino G, Cesarini M,
Tsianos EV, Louis E, Ben-Horin S.
Aliment Pharmacol Ther. 2011 Feb;33(3):349-57. doi: 10.1111/j.1365-2036.2010.04523.x. Epub 2010 Dec 1.
PMID: 21118397 [PubMed - indexed for MEDLINE] Free Article